Calon et al. demonstrated that depletion of dietary ω-3 fatty acids in mice overexpressing human Alzheimer’s disease gene APPswe (Tg2576) via treatment with safflower oil resulted in the activation of pro-apoptotic caspase-3 and N-methyl-D-aspartate receptor subunits (NR2A and NR2B) in cortex and hippocampus, and decreased the NR1 subunit in the hippocampus in addition to the decrease in the Ca2+/calmodulin-dependent protein kinase (CaMKII) in the cortex of transgenic animals. Here, GRIN2A is linked to early-onset autosomal dominant Alzheimer disease.