MBTPS1 and Huntington disease: What makes our findings attractive is the evidence that S1P metabolism may represent a target for the discovery of novel therapeutic strategies in HD, especially given that drugs working through its related pathways are already in clinical trials for different other pathological conditions (Kunkel et al., 2013; Gonzalez-Cabrera et al., 2014; O’Sullivan and Dev, 2017; Di Pardo and Maglione, 2018a).