BDNF and cognition: Moreover, reduced BDNF levels in the plasma of alcohol-dependent patients correlated with severe scores of cognition deficits, whereas chronic consumption and reinstatement of ethanol in adolescent rats was associated with lower plasma levels of BDNF, as well as with decreases in Bdnf mRNA levels, phosphorylated ERK2 levels and neurogenic responses (Mki67, Sox2, Dcx, Ncam1, and Calb1) in the hippocampus (Silva-Peña et al., 2018).