In a follow-up study, using immunostaining and double-labeling immunofluorescence, endocannabinoid-inactivating enzymes, e.g., FAAH, MAGL, were detected in the granular layer, Purkinje cells, neurons of the dentate nucleus and areas of white matter at levels notably higher in SCA patients (Rodríguez-Cueto et al., 2014b), then supporting a reduction of endocannabinoid levels in these areas due to an excessive degradation by these enzymes. Here, MGLL is linked to autosomal dominant cerebellar ataxia.