NOTCH1 and Alzheimer disease: Additional DEG included CXCR4 (brain development and neuronal cell survival in the hippocampus) (Stelzer et al., 2016; Li and Wang, 2017), AHNAK (may have a role in development of neuronal cells) (Gentil et al., 2005; Stelzer et al., 2016), NOTCH1,and NOTCH2 (signaling pathway may be involved in brain development) (Ables et al., 2011; Stelzer et al., 2016) which were all up-regulated in AD subjects (Table 4).