RNF135 and Alzheimer disease: Ten of our sex impacted disease genes (CYBRD1, DIRAS2, FAM107B, FOS, GMPR, HVCN1, ITIH5, MAPK, RNF135, SLC40A1) did not overlap with their findings, and these genes have been previously associated with oxidative stress, cell signaling and transport, apoptosis and AD.