On the other hand, RPA3 (DNA replication), NME1 (neural development) (Owlanj et al., 2012; Stelzer et al., 2016), and mitochondrial proteins MRPL3, MRPS18C (associated with mitochondrial dysfunction observed in AD) were down-regulated in AD samples (Table 4). Here, NME1 is linked to Alzheimer disease.