Specifically, genes in the Mitochondrial translation pathway that were down-regulated in AD included MRPL15, MPRL13, and MRPL1, which are all mitochondrial ribosomal proteins necessary for protein synthesis (Pearce et al., 2013; Stelzer et al., 2016; Fabregat et al., 2017). The gene discussed is MRPL1; the disease is Alzheimer disease.