However, genes in group 2 include DDR2 (regulates TREM2, microglia and neurotoxic proteins) (Hebron et al., 2017), IP6K3 (Inositol phosphate metabolism) (Crocco et al., 2016), and GJA1 (regulates known AD risk factor genes) (Kajiwara et al., 2018). The gene discussed is IP6K3; the disease is Alzheimer disease.