Moreover, the link between stressor-evoked increases in CRP and proinflammatory cytokines and depression appears to be bidirectional, as chronic stressors and current depressive symptoms, both associated with neurophysiological changes (e.g., glucocorticoid resistance), were found to increase stress reactivity, including cytokine changes in response to stressful challenges. The gene discussed is CRP; the disease is depressive symptom measurement.