PRNP and proteostasis deficiencies: Mounting evidence suggests that the key self-aggregating proteins in different proteinopathies, such as Aβ, PrPc and α-syn may share similar biophysical properties that affect the biochemical interrelations with membrane-integrated molecular compounds (Goedert, 2015; Ugalde et al., 2016; Goedert et al., 2017).