Interestingly, persistent secretion of TNF-α by microglia in the MHB of mice fed a high fat/high carbohydrate (HFHC) diet was reported to cause dysfunction in anorexigenic neurons that produce proopiomelanocortin (POMC) (Yi et al., 2017), a characteristic feature of obesity (Pinto et al., 2004; Horvath et al., 2010). Here, POMC is linked to obesity due to melanocortin 4 receptor deficiency.