With regards to microglial metabolism in obesity, it was recently reported that impairing lipid uptake, through the silencing of lipoprotein lipase (LPL), specifically in microglia, exacerbates weight gain and glucose intolerance in mice fed an HFHC diet (Gao et al., 2017). Here, LPL is linked to obesity due to melanocortin 4 receptor deficiency.