PPARG and Insulin resistance: Interestingly, the pharmacological inhibition of PPARγ or genetic inhibition of mitochondrial fatty acid oxidation in macrophages stimulated with SFAs exacerbate inflammation, and PPARγ deletion in macrophages aggravates insulin resistance in mice fed a HFD (Odegaard et al., 2007; Kratz et al., 2014; Namgaladze et al., 2014).