As shown in Fig. 6, platelets isolated in the acute phase from dengue-infected patients, but not platelets from HIV plus dengue-coinfected patients, released higher levels of PF4/CXCL4 and RANTES/CCL5 when incubated ex vivo compared to platelets from the same patients collected and examined at the recovery (Fig. 6A and B). This evidence concerns the gene CCL5 and dengue disease.