Given that Snail1 is positively regulated by mTORC245, and that Snail1 suppresses CK8/18 and ERα expression during EMT45,54,55, we conclude that CX-5461-mediated inhibition of rRNA biogenesis in vivo induces tumor differentiation through the disruption of an mTORC2/Snail1/ERα signaling axis. This evidence concerns the gene ESR1 and neoplasm.