These attempts include the analysis of circulating tumor cells [1], circulating cell-free tumor DNA [2], gene expression profiles from bronchoscopy obtained tumor samples [3], the analysis of common somatic mutations and rearrangements in specific genes including EGFR, ALK, ROS1, Her2, BRAF, KRAS, PTEN [4] and the analysis of blood serum proteins [5]. The gene discussed is PTEN; the disease is neoplasm.