Comparison of the CRC results across the three species showed that 10 out of 26 TFs are consistent in all of them, including CEBPA, BHLHE40, CEBPD, FOXO3, IRF2, KLF13, MNT, RXRA, SMAD3, and ZBTB (Figure 4f, Supplementary Materials Table S13). The gene discussed is SMAD3; the disease is colorectal carcinoma.