Herein, for the first time, we discovered that the natural sting crude extracts of Dm, Ut, and Ao impaired the structures of stratum corneum, stratum granulosum, and stratum spinosum of mouse skin epidermis (Figure 2) to boost the skin permeation of the insulin and insulin sensitizers (curcumin and rutin) for reducing the blood glucose level in diabetic ICR mice (Figure 4) while causing slight skin erythema without skin edema (Figure 1) or any damage to the HaCaT human skin keratinocytes (Figure 3). The gene discussed is INS; the disease is Erythema.