CD274 and neoplasm: In the KEYNOTE-010 [57], a Phase II/III randomized trial, 1034 patients already treated with a previous chemotherapy regimen (70% one line, 30% with two or more chemotherapeutic lines) expressing PD-L1 on at least 1% of tumor cells, were enrolled to establish the role of pembrolizumab (at two different doses of 2 and 10 mg/kg) as a second-line therapy compared to docetaxel.