Among patients with strongly positive PD-L1 (defined as the expression of PD-L1 in at least 50% of tumor cells), OS and PFS were significantly higher with pembrolizumab, regardless of the dose, than docetaxel (median OS: 14.9 and 17.3 months with pembrolizumab at 2 and 10 mg/kg, respectively, compared with 8.2 months with docetaxel; median PFS: 5.0 and 5.2 months with pembrolizumab at 2 and 10 mg/kg, respectively, compared to 4.1 months with docetaxel). Here, CD274 is linked to neoplasm.