In striking contrast to melanoma cells, in which the IL-6-gp130/ JAK1-ROCK axis is required for the amoeboid-like individual tumor migration, this signaling pathway is not required for the migration of squamous carcinoma cells themselves, but is required for CAFs to remodel the matrix, which is necessary for promoting the collective invasion of these carcinoma cells [64]. This evidence concerns the gene IL6 and melanoma.