GM2A and psoriasis: The gene expression profile of the HaCaT cells with “psoriasis-like” inflammation in relation to skin tissue (both PP and PN) shows that the only common up-regulated gene (fold change, FC ≥ 1.3) was GM2A. In addition, increased expression of the MTORC1 gene was seen only in activated HaCaT cells and in 73% of PP and 91% of PN skin samples (Figure S1).