It is important to determine the potential consequences of changes in the amount and morphology of lysosomes and other acidic organelles in psoriasis, which may be manifested, among others, in disturbed processes of apoptosis and autophagy, abnormalities of sphingolipid and ceramide metabolism pathways, incorrect presentation of antigens by major histocompatibility complex (MHC) class II molecules or increased transcription of genes encoding selected proinflammatory cytokines and chemokines—processes being deregulated in this dermatosis. Here, HLA-C is linked to psoriasis.