In all staining tests, i.e., in the presence of LysoTracker, anti-lysosomal-associated membrane protein 1 (LAMP1) antibodies, and acridine orange (AO), an augmented level of lysosomes in HaCaT cells with “psoriasis-like” inflammation was found relative to the non-activated HaCaT cell control cultured in medium containing either Ca2+ ≤ 0.1 mM or 2 mM Ca2+. Here, LAMP1 is linked to psoriasis.