ZAP70 and B-cell chronic lymphocytic leukemia: However, correlations between the therapy response and the expression of immunological and genetic markers, which play a prognostic role in CLL and predict short treatment free survival and poor outcome, including ZAP-70 [57] and ATM(11q22.3) [58], were detected (r = 0.25 and r = 0.41, respectively) (Figure 3C).