Correlations between the therapy response and the immaturity markers, which are the most useful ways of detecting minimal residual disease and predicting relapse in ALL [49], were also found: A strong correlation with CD34 (r = 0.76) and a moderate correlation with HLA-DR (r = 0.65) and TdT (r = 0.33). The gene discussed is DNTT; the disease is acute lymphoblastic leukemia.