HIF1A and cancer: The cells with increased OxPhos and glycolysis possess high membrane potential in mitochondria, which is one notable indicator of the cells that will transit to the late stage of reprogramming and acquire the pluripotent state [85] As c-MYC and HIF1α cooperate to reprogram metabolism in cancer cells under hypoxic conditions [89,90], these transcription factors probably cooperate similarly to induce the metabolic shift during reprogramming.