The increase in apoptosis was associated with the up-regulation of the caspase cascade including DNA fragmentation, pro-apoptotic Bax expression and translocation of cytochrome-c from the mitochondria to the cytosol and down-regulation of anti-apoptotic Bcl-2 and Bcl-xl in different human cancer cells [86,87,88,89]. Here, BCL2L1 is linked to cancer.