PRRT2 and malignant colon neoplasm: In colon cancer cells with pre-treatment with butyrate, cholinergic stimulation or phorbolester treatment enhances activation of calcium-dependent PKC to induce an increase in membrane-bound cPKC activity and radically reduce expression of distinct high- molecular CD44 variant transcripts v3 (670 bp), v5 (940 bp) and v8 (535 bp) [134].