Acute promyelocytic leukemia (APL) is a hematological malignancy commonly associated with the chromosomal translocation t(15;17)(q24;q21), which involves the promyelocytic leukemia (PML) and the retinoic acid receptor-α (RARα) genes, resulting in the oncogenic fusion transcript PML-RARα [37]. The gene discussed is RARA; the disease is leukemia.