MYC and infection: While doubts remain about the specificity of Ca2+ signatures during pre-infection, at later symbiosis stages, the patterns of Ca2+ oscillations are similar in both Myc and Nod symbioses and related instead to the stage of infection [46]: in both symbioses, Ca2+ spiking switches from infrequent and irregular, to a pattern of high-frequency regular oscillations when transcellular infection begins [46].