STAT3 and non-small cell lung carcinoma: However, it is still possible that regulation of EMT is not the sole mechanism of the anti-migration effects of MEMA based on the following points: (i) Although the expression of EMT marker proteins, up-regulated or down-regulated by MEMA, was almost recovered by overexpression of STAT3 CA, the migratory ability of NSCLC cells was not completely compensated by transfection of STAT3 CA (Figure 6).