CXCL8 and ovarian carcinoma: Vorinostat has also been shown to induce the IL-8/CXCL8 expression in ovarian cancer cells, which is dependent on IκB kinase (IKK) activity and is associated with gene-specific recruitment of IKKβ and IKK-dependent recruitment of p65 NFκB to the IL-8/CXCL8 promoter [131].