Additionally, using catalytically dead Cas9-Krüppel-associated box domain (dCas9-KRAB) to silence various enhancer constituents of the oncogenic sphingosine kinase 1 (SPHK1) led to a decrease in its levels, which was associated with attenuated proliferation and migration in hepatocellular carcinoma [24,25]. The gene discussed is SPHK1; the disease is hepatocellular carcinoma.