The CD47/SIRPα axis has been targeted with anti-CD47 blocking antibodies and non-functional engineered SIRPα variants, in combination with anti-tumor therapeutic antibodies such as Rituximab, Cetuximab, and Trastuzumab, displaying synergistic activity in augmenting macrophage phagocytosis [40]. The gene discussed is SIRPA; the disease is neoplasm.