IL6 and cancer: In the context of chronic inflammation, TAMs can create a mutagenic microenvironment that favors cancer initiation via the activation of transcription factors, including NFkB and STAT3, leading to the production of inflammatory products such as Interleukin 6 (IL-6), Interferon γ (IFNγ), TNF, growth factors, reactive oxygen/nitrogen species, and proteases [23].