Indeed, contributions to the efficacy of therapy by FcR-mediated immune response were reported for several antibodies, including Rituximab, a monoclonal antibody anti-CD20 used for lymphoma and leukemia treatment, Cetuximab, targeting the epidermal growth factor receptor (EGFR), Trastuzumab, an antibody directed against the epidermal growth factor receptor HER2/Erbb2, and Daratumumab, an anti-CD38 antibody for myeloma [39]. This evidence concerns the gene ERBB2 and plasma cell myeloma.