In particular, in melanoma, both in preclinical and in clinical settings, treatment with antibodies directed against CTLA-4 and glucocorticoid-induced TNFR-related protein (GITR) induced Treg depletion in an fragment crystallizable (Fc)-γ receptor (FcγR) -mediated manner [36,37]. This evidence concerns the gene TNFRSF18 and melanoma.