Overall, nonsynonymous mutations in myocilin are responsible for approximately 3% to 5% of the 70 million open angle glaucoma cases worldwide.11 These changes in amino acid sequence result in reduced OLF stability,12 protein aggregation and intracellular accumulation in endoplasmic reticulum (ER).13,14 An anomalous interaction with the ER-resident molecular chaperone Grp9415 leads to ER stress15, , , , , –21 and cell death,13,17 hastening the hallmark glaucoma risk factor of increased intraocular pressure. Here, MYOC is linked to glaucoma.