BRCA1 and breast cancer: Germline BRCA1, BRCA2 and PALB2 mutations are alsoassociated with an increased risk of developing male breast cancer (MBC) (Thompson et al., 2002; Levy-Lahad and Friedman, 2007; Rahman et al., 2007).Although corresponding to less than 1% of all BC cases, a significant proportion ofMBCs arise in a setting of familial BC (Anderson andBadzioch, 1992; Hemminki and Vaittinen,1999; Weiss et al.,2005).