PALB2 and breast cancer: Couch et al. (2017) showed that pathogenicmutations in PALB2 are in fact associated with a high-risk of BC(odds ratio 7.5). Based on data from different populations, PALB2germline mutations appear to account for approximately 0.7-1.1% of all familialaggregation of BC (Rahman et al.,2007; Buys et al.,2017; Eliade et al.,2017). PALB2 has also been reported as a susceptibilitygene for pancreatic cancer (Jones etal., 2009b; Tischkowitzet al., 2009; Slater et al., 2010).