PALB2 and breast neoplasm: King etal. (2007) have suggested that LOH is not required for thetumorigenesis of BRCA breast tumors, since a high level of heterogeneity to thismolecular event within and between pre-invasive lesions and invasive cancers wasfound. For PALB2-related BCs, the few reports to date have found controversialresults regarding LOH of PALB2 (Tischkowitz et al., 2007; Hartley et al., 2014).