BRCA2 and breast neoplasm: With regard to CNAs, BRCA1 and BRCA2 breast tumors show different patterns of gainsand losses compared to sporadic tumors (Jönssonet al., 2005), and despite overlaps between BRCA1and BRCA2 tumors many differences have been observed at this genomic level (van der Groep et al., 2011).For PALB2 breast tumors, 1q gain, 20q gain, and 18q loss were consistently observedacross tumors (Tischkowitz et al.,2007).