A large number of rare germline variants has been reported throughout both genesaccording to the Breast Cancer Information Core website (BIC) (approximately 1800mutations in BRCA1 and 2000 mutations in BRCA2),and the majority of those have not been reported as recurrent (Breast CancerInformation Core; http://www.research.nhgri.nih.gov/bic). The gene discussed is BRCA1; the disease is breast cancer.