It is remarkable that BRCA1, BRCA2 and PALB2-deficient cells exhibitspontaneously single sister chromatid breaks, quadri and triradial chromosomes,as well as translocations, large deletions, and fusions involving non-homologouschromosomes (Shen et al.,1998; Yu et al.,2000; Moynahan 2002; Nikkilä et al., 2013).Most importantly, DSB seems to be the typical structural aberration found inBRCA-deficient cells, suggesting that HR is important for tumor suppression(Venkitaraman, 2014). Here, BRCA1 is linked to neoplasm.