HMGA2 and cancer: In addition to the HT1080 fibrosarcoma cells, we utilized cervical carcinoma HeLa and lung adenocarcinoma A549 cancer cell models in which exogenous human HMGA2 is expressed at different levels and can be compared to the corresponding parental cells which do not express detectable protein levels, as determined by Western blot analysis (Fig 1) (HeLa parental and HeLa P2/P8/P19 (Fig 1A); A549 parental and A549 1.3/1.5/1.6 cell lines (Fig 1B); [33]).