Results of the multivariate Cox proportional hazard regression showed that RP could reduce more risks of OM and CSM after adjusted for race, age, marital status, GS and PSA (hazard ratio [HR]=0.54, 95% CI = 0.47‐0.62, P < 0.001 and HR = 0.30, 95% CI = 0.20‐0.45, P < 0.001, respectively). This evidence concerns the gene KLK3 and ocular melanoma.