Sun et al showed that XIST inhibition could reduce inflammatory pain through inhibiting Nav1.7 by acting as a sponge for miR‐146a, suggesting a promising strategy for fighting inflammatory pain.23 Moreover, XIST knockdown inhibited neuroinflammation by suppressing TNF‐α, COX‐2, and IL‐6 expression in CCI rats.24, 25 However, there are few literature studies on the function and mechanism of XIST in pneumonia. This evidence concerns the gene XIST and susceptibility to pneumonia measurement.