As 2p gain often involves the whole short arm of chromosome 2, we decided to study two previously described minimal regions of gain: 2p24 and 2p15‐16.10, 12, 13, 18, 20, 22 The 2p24 region encompasses MYCN, and the 2p15‐16 encompasses XPO1 and REL, all of which are overexpressed in 2p+ CLL.13MYCN and REL are already known oncogenes involved in lymphoid malignancies. Here, REL is linked to B-cell chronic lymphocytic leukemia.