REL and B-cell chronic lymphocytic leukemia: Moreover, we have shown that the gene coding for exportin 1 (XPO1, located in 2p) has a central role in drug resistance in 2p+ CLL.12, 13 However, as the whole short arm of chromosome 2 is often gained in patients with 2p+ CLL, other known proto‐oncogenes located in the same region (such as REL and MYCN) might also be associated with CLL drug resistance.9, 10, 11, 12, 13