MYCN (a member of the MYC family) is associated with a variety of tumors, including neuroblastoma.23REL encodes a member of the NF‐Κb family of transcription factors involved in cell growth and differentiation, and is overexpressed in Hodgkin's lymphoma.24 Lastly, we recently highlighted the role of XPO1 (coding for exportin 1) in the drug resistance associated with 2p+.13 In the majority of cases in our series, the three oncogenes had been gained together in the same proportions—thus confirming their relevance in CLL drug resistance. Here, MYCN is linked to B-cell chronic lymphocytic leukemia.