MAPT and Alzheimer disease: Several teams evaluated potential links between AD and BIN1 and determined: (1) BIN1 may regulate BACE1 intracellular trafficking through multiple mechanisms and subsequently alter Aβ peptide production [39]; (2) BIN1 may have a role in plasma membrane remodeling during myelination, which is known to be affected in AD [19, 38]; (3) BIN1 may participate in the neuron-to-neuron propagation of Tau prion strains [12]; and (4) BIN1 may directly interact with Tau and interfere with Tau neurotoxicity via unknown mechanisms [20, 37].