MAPT and tauopathy: For this purpose, we crossed the hTau mouse, a tauopathy model that overexpresses human MAPT (but does not express endogenous murine Mapt [42]) with the TgBIN1 mouse that overexpresses human BIN1 under the control of its own promoter and recapitulates the tissue-specific expression of two main BIN1 isoforms (isoform 1 and isoform 8) (Fig. S7) [18].