MAPT and tauopathy: Briefly, generation of mice were obtained on C57BL/6 J genetic background by crossing Mapt+/−;TgMAPT/0 [2] and Mapt+/−;TgBIN1/0 [18] to obtain Mapt+/− as control littermates, Mapt−/−;TgMAPT/0 (noted here hTau) as the tauopathy model [42], and, finally, Mapt−/−;TgMAPT/0;TgBIN1/0 as the double transgenic model (noted here hTau;TgBIN1).