SRSF2 and chronic myelomonocytic leukemia: Meanwhile, SRSF2 mutations are more common in chronic myelomonocytic leukemia, which alter the RNA-binding characteristics of SRSF2, thereby resulting in extensive changes in splicing patterns and impairment of hematopoietic cell differentiation (Yoshida and Ogawa, 2014; Shiozawa et al., 2018).