The CLKs family consist of four members that could phosphorylate SR proteins to regulate cancer-related alternative splicing events, such as CLK1 phosphorylates splicing factor 45 (SPF45) to induce migration and invasion of ovarian cancer cells (Ngo et al., 2005; Ninomiya et al., 2011; Silipo et al., 2015). The gene discussed is RBM17; the disease is cancer.