In order to identify the underlying mechanisms, we analyzed the expression levels of NOTCH2 in the parental and KDM6A and KDM6B knockdown CRC cells by qRT-PCR; the results indicated that knockdown of KDM6A and KDM6B downregulated the NOTCH2 expression (Figure 6C). The gene discussed is NOTCH2; the disease is colorectal carcinoma.