PTH and adenoma: There was no persistent disease (defined as a failure to maintain normal serum calcium and PTH levels in the 12 months postoperatively) and one recurrence (defined as pHPT after a minimum of 12 months of normal biochemistry): patient 2, who had undergone targeted surgery, presented after 5 years with biochemically mild recurrent pHPT and opted for reoperation 8 years later, at which time a second adenoma was removed.