Then, a series of experiments confirmed that STAT3 was the key target protein in the process by which miR‐125b‐5p inhibited the growth, EMT, and CSC of HCC cells and that activation of the miR‐125b‐5p/STAT3 axis effectively reversed the EMT process and inhibited the stemness potential. The gene discussed is STAT3; the disease is hepatocellular carcinoma.