After treatment with the miR‐125b‐5p‐loaded nanomedicine, the epithelial markers E‐cadherin and α‐Catenin were upregulated but the mesenchymal markers Vimentin, Fibronectin, MMP2, MMP9, SNAIL, and SLUG were downregulated in the HCCLM3 and HUH7 tumor tissues, as determined by RT‐PCR and western blotting assays (Figure 7C,E, P < 0.01). This evidence concerns the gene SNAI2 and neoplasm.