This observation was of importance because previous studies have reported that CD146 was an oncoprotein in melanoma.19 In consistent with the unsatisfactory treatment efficacy of IR700‐IgG PIT, H&E and immunofluorescence staining of the collected tumor tissue showed that the majority of the tumor cells were viable with abundant CD146 expression (Figure8A,C). The gene discussed is MCAM; the disease is neoplasm.