On the other hand, the dominant expression of CD146 in melanoma (i.e., in ≈70% of primary melanomas and 90% of lymph node metastases) renders this marker a potential candidate for identifying both primary and metastatic melanomas.39 Herein, we investigated and reported that 89Zr‐Df‐YY146 PET readily and accurately identified CD146‐positive melanomas. Here, MCAM is linked to metastatic malignant neoplasm in the lymph nodes.