One can envision that this CD146‐targeted PET imaging technique could detect nodal and distant melanoma metastases since CD146‐positive circulating tumor cells have been found in late‐stage melanoma patients,40 and CD146 is closely associated with melanoma lung metastases.20 The potential clinical application of CD146‐targeted 89Zr‐Df‐YY146 PET is to noninvasively assess CD146 status and heterogeneity in those sites that may not be accessible by biopsy, aiding in the selection of patients for CD146‐targeted therapies in an image‐guided manner. This evidence concerns the gene MCAM and neoplasm.