AKT1 and infection: Many DNA and RNA viruses have induced PI3K-Akt signaling pathway for virus survival during infection; these viruses modulate this pathway to optimise the virus entry and replication, virions assembly, latency and reactivation from latency, and apoptosis suppression (Darr, Mauser & Kenney, 2001; Cooray, 2004; Ehrhardt et al., 2006; Saeed et al., 2008; Dunn & Connor, 2011; Yogev & Boshoff, 2013).