A large body of evidence has linked obesity to cancer because obesity leads to an increase in inflammatory markers (IL-6 and TNF‐α) [30], insulin resistance [31], and adipokine secretions [32], all of which favor tumor survival and proliferation [33], while exercise has also shown to have potential anti-inflammatory effects by reducing of TNF‐α expression [34]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.