Aiming to uncover irisin's relation to other types of cancers, two studies conducted on lung cancer cells concluded that an increase in irisin levels led to a decrease in lung cancer cell proliferation, viability, and invasiveness by affecting the epithelial-mesenchymal transition (EMT), significantly decreasing the EMT markers N-cadherin and vimentin and increasing the expression of E-cadherin. This evidence concerns the gene FNDC5 and cancer.