In order to test whether several markers reported to be important in the dermal and epidermal embryonic and postnatal development, such as CRAPB1, Nestin, Ephrin B2C (C-terminus marker), and B2N (N-terminus marker), are conserved in various human tumours of skin appendages, the number of cells, amount of expression, and localization of these markers were analysed in 45 human basal cell carcinomas (BCC, superficial, nodular, adenoid, infiltrating, and sclerosing types), 13 sebaceous adenomas and carcinomas, 20 eccrine sweat gland tumours, and 5 pilomatricomas. The gene discussed is NES; the disease is neoplasm.