For this study, we have selected three markers: CRABP1, Nestin, and Ephrin B2, to test whether they are expressed in tumours or tumour stroma of skin adnexal tumours since it has been reported previously that they are (a) involved in human embryology and development of the epidermal and especially dermal compartment and (b) expressed in skin cancer. The gene discussed is NES; the disease is skin neoplasm.