Varghese et al. [74] demonstrated distinct gene upregulation of IGF1, HIF1, TIMP2, mTOH, COH17, and MSLN in peritoneal metastasis compared to other metastatic sites, suggesting a role for these molecular targets in peritoneal dissemination of colorectal cancer and furthermore indicating a possible role for these targets in the development of peritoneal surface specific anticancer treatments. This evidence concerns the gene IGF1 and colorectal cancer.