Anti-nuclear antibody (ANA) was positive in low titres (1:80 speckled) and extractable nuclear antigens (ENA) were absent; anti-cardiolipin IgG/IgM and lupus anti-coagulant were negative (Table 2); erythrocyte sedimentation rate (ESR) by Westergren's method was 42mm in 1st hour and C-reactive protein (CRP) was 36.4 mg/L. The gene discussed is BTG3; the disease is systemic lupus erythematosus.