Compared with model group, the abnormal concentration of arachidonic acid and 11b-PGF2a were called back, and the cytochrome p450 and the enzyme prostaglandin-F synthase are down-regulated Ginsenoside Rg1 treatment, which indicate that Ginsenoside Rg1 effectively reduce oxidative stress and inflammation reaction in AD mice. This evidence concerns the gene AKR1C3 and Alzheimer disease.