The apolipoproteins accelerate neuronal Aβ uptake, lysosomal trafficking and degradation in an isoform-dependent manner with apolipoprotein E3 more efficiently facilitating Aβ trafficking and degradation than apolipoprotein E4, a risk factor for AD and DLB28, thus linking both GBA, APOE and SNCA. The gene discussed is GBA1; the disease is Alzheimer disease.