Since the oncogenic Bcl-2 protein inhibits apoptosis by binding Bax and other factors, as well as autophagy by interacting with Beclin 1, its down-regulation found in both MCF-7 and MDA-MB-231 as a consequence of the HoThyRu/DOTAP treatment can predispose BCC to both apoptosis and autophagy. This evidence concerns the gene BECN1 and skin basal cell carcinoma.