To investigate a broader utility of TRuC-T cells, we generated TRuC-T cells using antibody domains specific for the multiple myeloma target B Cell Maturation Antigen (BCMA) and for the glioblastoma multiforme (GBM) target interleukin-13 receptor α2 (IL-13Rα2). Here, TNFRSF17 is linked to plasma cell myeloma.