In additional examples, T2D enhancer variants at the 11p15 locus near KCNQ1 looped to the CDKN1C promoter as well as to the INS/IGF2 locus 700 kb distal (Supplementary Fig. 4c), and T2D enhancer variants at the 10q22 locus near ZMIZ1 looped to the POLR3A locus 1 MB distal (Supplementary Fig. 4d). The gene discussed is IGF2; the disease is type 2 diabetes mellitus.