For example, at the 3q27 locus T2D variants directly looped to the TPRG1 promoter 900 kb distal (Supplementary Fig. 4a), and at the 10p13 locus T2D variants looped to the OPTN and CCDC3 promoters 840 kb distal (Supplementary Fig. 4b). Here, OPTN is linked to type 2 diabetes mellitus.