Analysis showed that, at 12 weeks of age, hepatic DNA methylation of Lpin1 TF binding region 2 (Chr12: 16,590,890–16,591,130 bp) was significantly increased (Δ = 7.1%, q = 0.002) in HF/HF offspring compared with LF/HF offspring (Fig. 5). Here, LPIN1 is linked to hydrops fetalis.