FGFR2 and Apert syndrome: We performed quantitative morphometric analysis of 3D micro computed tomography (μCT) image data of three mouse models with differing activating Fgfr2 mutations to determine the differential effects of these mutations on the mandible: two Apert syndrome mouse models, Fgfr2+/S252W (Wang et al., 2005) and Fgfr2+/P253R (Wang et al., 2010) on a C57BL6/J background, and a mouse model with a mutation associated with Crouzon and Pfeiffer syndromes, Fgfr2cC342Y/+ (Eswarakumar et al., 2004) on a CD1 background.