ASXL1 and myelodysplastic syndrome: In another study, animals with hematopoietic-cell-specific homozygous loss of Asxl1 developed progressive myelodysplasia culminating in MDS, an outcome that was attributed to loss of PRC2-mediated trimethylation of H3K27 (Abdel-Wahab et al., 2012a, 2013).