ASXL1 and myeloid neoplasm: Recent reports have called attention to the fact that nonsense and frameshift mutations of ASXL1 in human myeloid malignancies often truncate the protein after 404 to 800 amino acids, retaining the ASX homology domain and truncating off the remainder of this 1541 amino acid protein, including the plant homeodomain (PHD) domain (Asada et al., 2018; Balasubramani et al., 2015; Hsu et al., 2017; Inoue et al., 2016; Kitamura, 2018; Metscher and Ahlberg, 1999; Nagase et al., 2018; Yang et al., 2018).